Everything about Methanofuran totally explained
Methanofuran describes a family of
chemical compounds found in
methanogenic
archaea. These species feature a 2-aminomethyl
furan linked to
phenoxy group. At least three different end groups are recognized: R = tricarboxyheptanoyl (methanofuran),
glutamyl-glutamyl (methanofuran b), tricarboxy-2-hydroxyheptanoyl (methanofuran c, see picture).
Formylation of MFR
Methanofuran converts to
formylmethanofuran in an early stage of methanogenesis.
The enzyme formylmethanofuran dehydrogenase (
EC: 1.2.99.5) formylates methanofuran using CO
2, the primary C1 source in methanogenesis.
Deformylation of MFR
The
enzyme formylmethanofuran:tetrahydromethanopterin formyltransferase
catalyzes the transfer of the
formyl group from formylmethanofuran to N5 on tetrahydromethanopterin, H
4MPT. This enzyme has been crystallized; it contains no
prosthetic group.
Further Information
Get more info on 'Methanofuran'.
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